| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 16-9-26 18:45 | FC Ararat-Armenia | Sparta Prag | 1:4 |
| 16-9-26 18:45 | Omonia Nicosia | Celta Vigo | 1:0 |
| 16-9-26 21:00 | Bayer 04 Leverkusen | NK Celje | 2:0 |
| 16-9-26 21:00 | AC Mailand | Benfica Lissabon | 0:2 |
| 16-9-26 21:00 | Hapoel Beër Sjeva | Dinamo Zagreb | 0:0 |
| 16-9-26 21:00 | Olympiakos Piräus | Jagiellonia Białystok | 2:1 |
| 16-9-26 21:00 | RSC Anderlecht | Olympique Lyon | 1:2 |
| 16-9-26 21:00 | SK Sturm Graz | Stade Rennes | 0:0 |
| 16-9-26 21:00 | AFC Sunderland | AZ Alkmaar | 1:0 |
| 17-9-26 18:45 | OFI Crete | 1899 Hoffenheim | -:- |
| 17-9-26 18:45 | Levski Sofia | FC Red Bull Salzburg | -:- |
| 17-9-26 21:00 | Besiktas Istanbul | Olympique Marseille | -:- |
| 17-9-26 21:00 | Celtic Glasgow | Ferencvárosi TC | -:- |
| 17-9-26 21:00 | Crystal Palace | Lech Poznan | -:- |
| 17-9-26 21:00 | Viktoria Pilsen | Royale Union Saint-Gilloise | -:- |
| 17-9-26 21:00 | Juventus Turin | NEC Nijmegen | -:- |
| 17-9-26 21:00 | Lillestroem SK | SCU Torreense | -:- |
| 17-9-26 21:00 | Real Sociedad | AFC Bournemouth | -:- |