Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 5-11-21 21:00 | 5-11-21 21:00 | FC Southampton | Aston Villa | 1:0 | 2 - 5 punten |
| 6-11-21 13:30 | 6-11-21 13:30 | Manchester United | Manchester City | 0:2 | 2 - 5 punten |
| 6-11-21 16:00 | 6-11-21 16:00 | Brentford FC | Norwich City | 1:2 | 2 - 5 punten |
| 6-11-21 16:00 | 6-11-21 16:00 | FC Chelsea | FC Burnley | 1:1 | 2 - 5 punten |
| 6-11-21 16:00 | 6-11-21 16:00 | Crystal Palace | Wolverhampton Wanderers | 2:0 | 2 - 5 punten |
| 6-11-21 18:30 | 6-11-21 18:30 | Brighton and Hove Albion | Newcastle United | 1:1 | 2 - 5 punten |
| 7-11-21 15:00 | 7-11-21 15:00 | FC Arsenal | FC Watford | 1:0 | 2 - 5 punten |
| 7-11-21 15:00 | 7-11-21 15:00 | FC Everton | Tottenham Hotspur | 0:0 | 2 - 5 punten |
| 7-11-21 15:00 | 7-11-21 15:00 | Leeds United | Leicester City | 1:1 | 2 - 5 punten |
| 7-11-21 17:30 | 7-11-21 17:30 | West Ham United | FC Liverpool | 3:2 | 2 - 5 punten |