Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 11-9-21 13:30 | 11-9-21 13:30 | Crystal Palace | Tottenham Hotspur | 3:0 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | Brentford FC | Brighton and Hove Albion | 0:1 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | Leicester City | Manchester City | 0:1 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | Manchester United | Newcastle United | 4:1 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | FC Southampton | West Ham United | 0:0 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | FC Arsenal | Norwich City | 1:0 | 2 - 5 punten |
| 11-9-21 16:00 | 11-9-21 16:00 | FC Watford | Wolverhampton Wanderers | 0:2 | 2 - 5 punten |
| 11-9-21 18:30 | 11-9-21 18:30 | FC Chelsea | Aston Villa | 3:0 | 2 - 5 punten |
| 12-9-21 17:30 | 12-9-21 17:30 | Leeds United | FC Liverpool | 0:3 | 2 - 5 punten |
| 13-9-21 21:00 | 13-9-21 21:00 | FC Everton | FC Burnley | 3:1 | 2 - 5 punten |