Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 21-8-21 18:30 | 21-8-21 18:30 | Hellas Verona | Sassuolo Calcio | 2:3 | 2 - 5 punten |
| 21-8-21 18:30 | 21-8-21 18:30 | Inter Mailand | FC Genua 1893 | 4:0 | 2 - 5 punten |
| 21-8-21 20:45 | 21-8-21 20:45 | FC Turin | Atalanta Bergamo | 1:2 | 2 - 5 punten |
| 21-8-21 20:45 | 21-8-21 20:45 | FC Empoli | Lazio Rom | 1:3 | 2 - 5 punten |
| 22-8-21 18:30 | 22-8-21 18:30 | FC Bologna | US Salernitana | 3:2 | 2 - 5 punten |
| 22-8-21 18:30 | 22-8-21 18:30 | Udinese Calcio | Juventus Turin | 2:2 | 2 - 5 punten |
| 22-8-21 20:45 | 22-8-21 20:45 | SSC Neapel | Venezia FC | 2:0 | 2 - 5 punten |
| 22-8-21 20:45 | 22-8-21 20:45 | AS Rom | AC Florenz | 3:1 | 2 - 5 punten |
| 23-8-21 18:30 | 23-8-21 18:30 | Cagliari Calcio | Spezia Calcio | 2:2 | 2 - 5 punten |
| 23-8-21 20:45 | 23-8-21 20:45 | Sampdoria Genua | AC Mailand | 0:1 | 2 - 5 punten |