Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 4-12-21 15:00 | 4-12-21 15:00 | AC Mailand | US Salernitana | 2:0 | 2 - 5 punten |
| 4-12-21 18:00 | 4-12-21 18:00 | AS Rom | Inter Mailand | 0:3 | 2 - 5 punten |
| 4-12-21 20:45 | 4-12-21 20:45 | SSC Neapel | Atalanta Bergamo | 2:3 | 2 - 5 punten |
| 5-12-21 12:30 | 5-12-21 12:30 | FC Bologna | AC Florenz | 2:3 | 2 - 5 punten |
| 5-12-21 15:00 | 5-12-21 15:00 | Spezia Calcio | Sassuolo Calcio | 2:2 | 2 - 5 punten |
| 5-12-21 15:00 | 5-12-21 15:00 | Venezia FC | Hellas Verona | 3:4 | 2 - 5 punten |
| 5-12-21 18:00 | 5-12-21 18:00 | Sampdoria Genua | Lazio Rom | 1:3 | 2 - 5 punten |
| 5-12-21 20:45 | 5-12-21 20:45 | Juventus Turin | FC Genua 1893 | 2:0 | 2 - 5 punten |
| 6-12-21 18:30 | 6-12-21 18:30 | FC Empoli | Udinese Calcio | 3:1 | 2 - 5 punten |
| 6-12-21 20:45 | 6-12-21 20:45 | Cagliari Calcio | FC Turin | 1:1 | 2 - 5 punten |