Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 17-12-21 18:30 | 17-12-21 18:30 | Lazio Rom | FC Genua 1893 | 3:1 | 2 - 5 punten |
| 17-12-21 20:45 | 17-12-21 20:45 | US Salernitana | Inter Mailand | 0:5 | 2 - 5 punten |
| 18-12-21 15:00 | 18-12-21 15:00 | Atalanta Bergamo | AS Rom | 1:4 | 2 - 5 punten |
| 18-12-21 18:00 | 18-12-21 18:00 | FC Bologna | Juventus Turin | 0:2 | 2 - 5 punten |
| 18-12-21 20:45 | 18-12-21 20:45 | Cagliari Calcio | Udinese Calcio | 0:4 | 2 - 5 punten |
| 19-12-21 12:30 | 19-12-21 12:30 | AC Florenz | Sassuolo Calcio | 2:2 | 2 - 5 punten |
| 19-12-21 15:00 | 19-12-21 15:00 | Spezia Calcio | FC Empoli | 1:1 | 2 - 5 punten |
| 19-12-21 18:00 | 19-12-21 18:00 | Sampdoria Genua | Venezia FC | 1:1 | 2 - 5 punten |
| 19-12-21 18:00 | 19-12-21 18:00 | FC Turin | Hellas Verona | 1:0 | 2 - 5 punten |
| 19-12-21 20:45 | 19-12-21 20:45 | AC Mailand | SSC Neapel | 0:1 | 2 - 5 punten |