Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 27-8-21 18:30 | 27-8-21 18:30 | Udinese Calcio | Venezia FC | 3:0 | 2 - 5 punten |
| 27-8-21 20:45 | 27-8-21 20:45 | Hellas Verona | Inter Mailand | 1:3 | 2 - 5 punten |
| 28-8-21 18:30 | 28-8-21 18:30 | Lazio Rom | Spezia Calcio | 6:1 | 2 - 5 punten |
| 28-8-21 18:30 | 28-8-21 18:30 | Atalanta Bergamo | FC Bologna | 0:0 | 2 - 5 punten |
| 28-8-21 20:45 | 28-8-21 20:45 | Juventus Turin | FC Empoli | 0:1 | 2 - 5 punten |
| 28-8-21 20:45 | 28-8-21 20:45 | AC Florenz | FC Turin | 2:1 | 2 - 5 punten |
| 29-8-21 18:30 | 29-8-21 18:30 | Sassuolo Calcio | Sampdoria Genua | 0:0 | 2 - 5 punten |
| 29-8-21 18:30 | 29-8-21 18:30 | FC Genua 1893 | SSC Neapel | 1:2 | 2 - 5 punten |
| 29-8-21 20:45 | 29-8-21 20:45 | US Salernitana | AS Rom | 0:4 | 2 - 5 punten |
| 29-8-21 20:45 | 29-8-21 20:45 | AC Mailand | Cagliari Calcio | 4:1 | 2 - 5 punten |