Speelschema
| Competitie | Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|---|
| DFB | 26-10-21 18:30 | 26-10-21 18:30 | Preußen Münster | Hertha BSC | 1:3 | 2 - 4 punten |
| DFB | 26-10-21 18:30 | 26-10-21 18:30 | SV Babelsberg 03 | RB Leipzig | 0:1 | 2 - 4 punten |
| DFB | 26-10-21 18:30 | 26-10-21 18:30 | TSV 1860 München | FC Schalke 04 | 1:0 | 2 - 4 punten |
| DFB | 26-10-21 18:30 | 26-10-21 18:30 | 1899 Hoffenheim | Holstein Kiel | 5:1 | 2 - 4 punten |
| DFB | 26-10-21 20:00 | 26-10-21 20:00 | Borussia Dortmund | FC Ingolstadt | 2:0 | 2 - 4 punten |
| DFB | 26-10-21 20:45 | 26-10-21 20:45 | 1. FC Nürnberg | Hamburger SV | 3:5n.p. | 2 - 4 punten |
| DFB | 26-10-21 20:45 | 26-10-21 20:45 | FSV Mainz 05 | Arminia Bielefeld | 3:2n.v. | 2 - 4 punten |
| DFB | 26-10-21 20:45 | 26-10-21 20:45 | VfL Osnabrück | SC Freiburg | 4:5n.p. | 2 - 4 punten |
| DFB | 27-10-21 18:30 | 27-10-21 18:30 | Dynamo Dresden | FC St. Pauli | 2:3n.v. | 2 - 4 punten |
| DFB | 27-10-21 18:30 | 27-10-21 18:30 | SV Waldhof Mannheim | 1. FC Union Berlin | 1:3n.v. | 2 - 4 punten |
| DFB | 27-10-21 18:30 | 27-10-21 18:30 | Bayer 04 Leverkusen | Karlsruher SC | 1:2 | 2 - 4 punten |
| DFB | 27-10-21 18:30 | 27-10-21 18:30 | VfL Bochum | FC Augsburg | 7:6n.p. | 2 - 4 punten |
| DFB | 27-10-21 20:45 | 27-10-21 20:45 | Bor. Mönchengladbach | FC Bayern München | 5:0 | 2 - 4 punten |
| DFB | 27-10-21 20:45 | 27-10-21 20:45 | Hannover 96 | Fortuna Düsseldorf | 3:0 | 2 - 4 punten |
| DFB | 27-10-21 20:45 | 27-10-21 20:45 | Jahn Regensburg | FC Hansa Rostock | 5:7n.p. | 2 - 4 punten |
| DFB | 27-10-21 20:45 | 27-10-21 20:45 | VfB Stuttgart | 1. FC Köln | 0:2 | 2 - 4 punten |
| 1.BL | 29-10-21 20:30 | 29-10-21 20:30 | 1899 Hoffenheim | Hertha BSC | 2:0 | 2 - 4 punten |
| 1.BL | 30-10-21 15:30 | 30-10-21 15:30 | Arminia Bielefeld | FSV Mainz 05 | 1:2 | 2 - 4 punten |
| 1.BL | 30-10-21 15:30 | 30-10-21 15:30 | SC Freiburg | SpVgg Greuther Fürth | 3:1 | 2 - 4 punten |
| 1.BL | 30-10-21 15:30 | 30-10-21 15:30 | 1. FC Union Berlin | FC Bayern München | 2:5 | 2 - 4 punten |
| 1.BL | 30-10-21 15:30 | 30-10-21 15:30 | Bayer 04 Leverkusen | VfL Wolfsburg | 0:2 | 2 - 4 punten |
| 1.BL | 30-10-21 15:30 | 30-10-21 15:30 | Borussia Dortmund | 1. FC Köln | 2:0 | 2 - 4 punten |
| 1.BL | 30-10-21 18:30 | 30-10-21 18:30 | Eintracht Frankfurt | RB Leipzig | 1:1 | 2 - 4 punten |
| 1.BL | 31-10-21 15:30 | 31-10-21 15:30 | FC Augsburg | VfB Stuttgart | 4:1 | 2 - 4 punten |
| 1.BL | 31-10-21 17:30 | 31-10-21 17:30 | Bor. Mönchengladbach | VfL Bochum | 2:1 | 2 - 4 punten |