Speelschema
| Competitie | Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|---|
| 1.BL | 27-8-21 20:30 | 27-8-21 20:30 | Borussia Dortmund | 1899 Hoffenheim | 3:2 | 2 - 4 punten |
| 2.BL | 28-8-21 13:30 | 28-8-21 13:30 | Holstein Kiel | Erzgebirge Aue | 3:0 | 2 - 4 punten |
| 2.BL | 28-8-21 13:30 | 28-8-21 13:30 | 1. FC Heidenheim 1846 | Hamburger SV | 0:0 | 2 - 4 punten |
| 1.BL | 28-8-21 15:30 | 28-8-21 15:30 | FC Augsburg | Bayer 04 Leverkusen | 1:4 | 2 - 4 punten |
| 1.BL | 28-8-21 15:30 | 28-8-21 15:30 | FSV Mainz 05 | SpVgg Greuther Fürth | 3:0 | 2 - 4 punten |
| 1.BL | 28-8-21 15:30 | 28-8-21 15:30 | VfB Stuttgart | SC Freiburg | 2:3 | 2 - 4 punten |
| 1.BL | 28-8-21 15:30 | 28-8-21 15:30 | 1. FC Köln | VfL Bochum | 2:1 | 2 - 4 punten |
| 1.BL | 28-8-21 15:30 | 28-8-21 15:30 | Arminia Bielefeld | Eintracht Frankfurt | 1:1 | 2 - 4 punten |
| 1.BL | 28-8-21 18:30 | 28-8-21 18:30 | FC Bayern München | Hertha BSC | 5:0 | 2 - 4 punten |
| 2.BL | 28-8-21 20:30 | 28-8-21 20:30 | FC Schalke 04 | Fortuna Düsseldorf | 3:1 | 2 - 4 punten |
| 2.BL | 29-8-21 13:30 | 29-8-21 13:30 | Werder Bremen | FC Hansa Rostock | 3:0 | 2 - 4 punten |
| 2.BL | 29-8-21 13:30 | 29-8-21 13:30 | FC St. Pauli | Jahn Regensburg | 2:0 | 2 - 4 punten |
| 1.BL | 29-8-21 15:30 | 29-8-21 15:30 | 1. FC Union Berlin | Bor. Mönchengladbach | 2:1 | 2 - 4 punten |
| 1.BL | 29-8-21 17:30 | 29-8-21 17:30 | VfL Wolfsburg | RB Leipzig | 1:0 | 2 - 4 punten |