| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 28-11-25 20:30 | FC Cesena | Modena FC | 1:0 |
| 29-11-25 15:00 | AC Reggiana 1919 | Frosinone Calcio | 0:1 |
| 29-11-25 15:00 | Pescara Calcio | Padova Calcio | 0:1 |
| 29-11-25 15:00 | Venezia FC | Mantova 1911 | 3:0 |
| 29-11-25 15:00 | FC Empoli | SSC Bari | 5:0 |
| 29-11-25 15:30 | FC Südtirol | US Avellino | 0:1 |
| 29-11-25 17:15 | US Catanzaro 1929 | Virtus Entella | 3:2 |
| 29-11-25 19:30 | Palermo FC | Carrarese Calcio 1908 | 5:0 |
| 30-11-25 15:00 | Juve Stabia | AC Monza | 2:2 |
| 30-11-25 17:15 | Spezia Calcio | Sampdoria Genua | 1:0 |
| 6-12-25 15:00 | Sassuolo Calcio | AC Florenz | 3:1 |
| 6-12-25 18:00 | Inter Mailand | Como Calcio | 4:0 |
| 6-12-25 20:45 | Hellas Verona | Atalanta Bergamo | 3:1 |
| 7-12-25 12:30 | US Cremonese | US Lecce | 2:0 |
| 7-12-25 15:00 | Cagliari Calcio | AS Rom | 1:0 |
| 7-12-25 18:00 | Lazio Rom | FC Bologna | 1:1 |
| 7-12-25 20:45 | SSC Neapel | Juventus Turin | 2:1 |
| 8-12-25 15:00 | Pisa Sporting Club | Parma Calcio 1913 | 0:1 |
| 8-12-25 18:00 | Udinese Calcio | Genua CFC | 1:2 |
| 8-12-25 20:45 | FC Turin | AC Mailand | 2:3 |