| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 29-8-25 18:30 | US Cremonese | Sassuolo Calcio | -:- |
| 29-8-25 20:30 | AC Reggiana 1919 | FC Empoli | -:- |
| 29-8-25 20:45 | US Lecce | AC Mailand | -:- |
| 30-8-25 18:30 | Parma Calcio 1913 | Atalanta Bergamo | -:- |
| 30-8-25 18:30 | FC Bologna | Como Calcio | -:- |
| 30-8-25 19:00 | Juve Stabia | Venezia FC | -:- |
| 30-8-25 19:00 | Mantova 1911 | Pescara Calcio | -:- |
| 30-8-25 20:45 | SSC Neapel | Cagliari Calcio | -:- |
| 30-8-25 20:45 | Pisa Sporting Club | AS Rom | -:- |
| 30-8-25 21:00 | FC Cesena | Virtus Entella | -:- |
| 30-8-25 21:00 | Palermo FC | Frosinone Calcio | -:- |
| 30-8-25 21:00 | Spezia Calcio | US Catanzaro 1929 | -:- |
| 31-8-25 18:30 | Genua CFC | Juventus Turin | -:- |
| 31-8-25 18:30 | FC Turin | AC Florenz | -:- |
| 31-8-25 19:00 | Carrarese Calcio 1908 | Padova Calcio | -:- |
| 31-8-25 19:00 | FC Südtirol | Sampdoria Genua | -:- |
| 31-8-25 20:45 | Lazio Rom | Hellas Verona | -:- |
| 31-8-25 20:45 | Inter Mailand | Udinese Calcio | -:- |
| 31-8-25 21:00 | SSC Bari | AC Monza | -:- |
| 31-8-25 21:00 | Modena FC | US Avellino | -:- |