| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 12-9-25 20:30 | US Avellino | AC Monza | 2:1 |
| 13-9-25 15:00 | Cagliari Calcio | Parma Calcio 1913 | 2:0 |
| 13-9-25 15:00 | Juve Stabia | AC Reggiana 1919 | 0:0 |
| 13-9-25 15:00 | Modena FC | SSC Bari | 3:0 |
| 13-9-25 15:00 | Padova Calcio | Frosinone Calcio | 0:1 |
| 13-9-25 15:00 | Pescara Calcio | Venezia FC | 2:2 |
| 13-9-25 17:15 | US Catanzaro 1929 | Carrarese Calcio 1908 | 1:1 |
| 13-9-25 18:00 | Juventus Turin | Inter Mailand | 4:3 |
| 13-9-25 19:30 | Sampdoria Genua | FC Cesena | 1:2 |
| 13-9-25 20:45 | AC Florenz | SSC Neapel | 1:3 |
| 14-9-25 12:30 | AS Rom | FC Turin | 0:1 |
| 14-9-25 15:00 | Atalanta Bergamo | US Lecce | 4:1 |
| 14-9-25 15:00 | Pisa Sporting Club | Udinese Calcio | 0:1 |
| 14-9-25 15:00 | Virtus Entella | Mantova 1911 | 1:0 |
| 14-9-25 17:15 | FC Südtirol | Palermo FC | 0:2 |
| 14-9-25 18:00 | Sassuolo Calcio | Lazio Rom | 1:0 |
| 14-9-25 19:30 | FC Empoli | Spezia Calcio | 1:1 |
| 14-9-25 20:45 | AC Mailand | FC Bologna | 1:0 |
| 15-9-25 18:30 | Hellas Verona | US Cremonese | 0:0 |
| 15-9-25 20:45 | Como Calcio | Genua CFC | 1:1 |