| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 23-9-25 17:00 | Cagliari Calcio | Frosinone Calcio | 4:1 |
| 23-9-25 18:30 | Udinese Calcio | Palermo FC | 2:1 |
| 23-9-25 21:00 | AC Mailand | US Lecce | 3:0 |
| 24-9-25 17:00 | Parma Calcio 1913 | Spezia Calcio | 6:5n.p./2:290m |
| 24-9-25 18:30 | Hellas Verona | Venezia FC | 4:5n.p./0:090m |
| 24-9-25 21:00 | Como Calcio | Sassuolo Calcio | 3:0 |
| 25-9-25 18:30 | Genua CFC | FC Empoli | 3:1 |
| 25-9-25 21:00 | FC Turin | Pisa Sporting Club | 1:0 |
| 30-9-25 20:30 | Palermo FC | Venezia FC | 0:0 |
| 30-9-25 20:30 | Juve Stabia | Mantova 1911 | 2:1 |
| 30-9-25 20:30 | Padova Calcio | US Avellino | 2:2 |
| 30-9-25 20:30 | AC Reggiana 1919 | Spezia Calcio | 1:1 |
| 30-9-25 20:30 | Virtus Entella | SSC Bari | 2:2 |
| 30-9-25 20:30 | Frosinone Calcio | FC Cesena | 3:1 |
| 1-10-25 20:30 | Pescara Calcio | FC Südtirol | 1:1 |
| 1-10-25 20:30 | Sampdoria Genua | US Catanzaro 1929 | 0:0 |
| 1-10-25 20:30 | Carrarese Calcio 1908 | Modena FC | 0:0 |
| 1-10-25 20:30 | FC Empoli | AC Monza | 1:1 |
| 3-10-25 20:45 | Hellas Verona | Sassuolo Calcio | 0:1 |
| 4-10-25 15:00 | Lazio Rom | FC Turin | 3:3 |
| 4-10-25 15:00 | Parma Calcio 1913 | US Lecce | 0:1 |
| 4-10-25 18:00 | Inter Mailand | US Cremonese | 4:1 |
| 4-10-25 20:45 | Atalanta Bergamo | Como Calcio | 1:1 |
| 5-10-25 12:30 | Udinese Calcio | Cagliari Calcio | 1:1 |
| 5-10-25 15:00 | FC Bologna | Pisa Sporting Club | 4:0 |
| 5-10-25 15:00 | AC Florenz | AS Rom | 1:2 |
| 5-10-25 18:00 | SSC Neapel | Genua CFC | 2:1 |
| 5-10-25 20:45 | Juventus Turin | AC Mailand | 0:0 |