| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 9-12-25 16:30 | Kairat Almaty | Olympiakos Piräus | 0:1 |
| 9-12-25 18:45 | FC Bayern München | Sporting Lissabon | 3:1 |
| 9-12-25 21:00 | AS Monaco | Galatasaray Istanbul | 1:0 |
| 9-12-25 21:00 | FC Barcelona | Eintracht Frankfurt | 2:1 |
| 9-12-25 21:00 | PSV Eindhoven | Atletico Madrid | 2:3 |
| 9-12-25 21:00 | Atalanta Bergamo | FC Chelsea | 2:1 |
| 9-12-25 21:00 | Tottenham Hotspur | Slavia Prag | 3:0 |
| 9-12-25 21:00 | Royale Union Saint-Gilloise | Olympique Marseille | 2:3 |
| 9-12-25 21:00 | Inter Mailand | FC Liverpool | 0:1 |
| 10-12-25 18:45 | FC Villarreal | FC Kopenhagen | 2:3 |
| 10-12-25 18:45 | Qarabag | Ajax Amsterdam | 2:4 |
| 10-12-25 21:00 | Athletic Bilbao | Paris St. Germain | 0:0 |
| 10-12-25 21:00 | Bayer 04 Leverkusen | Newcastle United | 2:2 |
| 10-12-25 21:00 | Borussia Dortmund | FK Bodö/Glimt | 2:2 |
| 10-12-25 21:00 | Club Brugge | FC Arsenal | 0:3 |
| 10-12-25 21:00 | Juventus Turin | Pafos FC | 2:0 |
| 10-12-25 21:00 | Real Madrid | Manchester City | 1:2 |
| 10-12-25 21:00 | Benfica Lissabon | SSC Neapel | 2:0 |