| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 6-11-25 18:45 | Samsunspor | Hamrun Spartans | 3:0 |
| 6-11-25 18:45 | Schachtjor Donezk | Breidablik Kopavogur | 2:0 |
| 6-11-25 18:45 | Sparta Prag | KS Rakow Czestochowa | 0:0 |
| 6-11-25 18:45 | NK Celje | Legia Warschau | 2:1 |
| 6-11-25 18:45 | Kuopion PS | SK Slovan Bratislava | 3:1 |
| 6-11-25 18:45 | AEK Athen | Shamrock Rovers | 1:1 |
| 6-11-25 18:45 | AEK Larnaka | FC Aberdeen | 0:0 |
| 6-11-25 18:45 | FC Noah | Sigma Olomouc | 1:2 |
| 6-11-25 18:45 | FSV Mainz 05 | AC Florenz | 2:1 |
| 6-11-25 21:00 | SK Rapid Wien | Universitatea Craiova | 0:1 |
| 6-11-25 21:00 | Dynamo Kiew | HŠK Zrinjski Mostar | 6:0 |
| 6-11-25 21:00 | Crystal Palace | AZ Alkmaar | 3:1 |
| 6-11-25 21:00 | Rayo Vallecano | Lech Poznan | 3:2 |
| 6-11-25 21:00 | Lincoln Red Imps FC | HNK Rijeka | 1:1 |
| 6-11-25 21:00 | KF Shkendija | Jagiellonia Białystok | 1:1 |
| 6-11-25 21:00 | BK Häcken | Racing Club Strasbourg | 1:2 |
| 6-11-25 21:00 | FC Lausanne-Sport | Omonia Nicosia | 1:1 |
| 6-11-25 21:00 | FC Shelbourne | KF Drita Gjilan | 0:1 |