| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 5-8-22 17:45 | Cagliari Calcio | AC Perugia | 3:2 |
| 5-8-22 18:00 | Udinese Calcio | FeralpiSalò | 2:1 |
| 5-8-22 21:00 | US Lecce | AS Cittadella | 2:3n.v. |
| 5-8-22 21:15 | Sampdoria Genua | Reggina 1914 | 1:0 |
| 6-8-22 17:45 | AC Pisa | Brescia Calcio | 1:4 |
| 6-8-22 18:00 | Spezia Calcio | Como Calcio | 5:1 |
| 6-8-22 21:00 | FC Empoli | SPAL Ferrara | 1:2n.v. |
| 6-8-22 21:15 | FC Turin | Palermo FC | 3:0 |
| 7-8-22 17:45 | Venezia FC | Ascoli Calcio | 2:3 |
| 7-8-22 18:00 | Hellas Verona | SSC Bari | 1:4 |
| 7-8-22 21:00 | US Salernitana | Parma Calcio 1913 | 0:2 |
| 7-8-22 21:15 | AC Monza | Frosinone Calcio | 3:2 |
| 8-8-22 17:45 | FC Genua 1893 | Benevento Calcio | 3:2 |
| 8-8-22 18:00 | Modena FC | Sassuolo Calcio | 3:2 |
| 8-8-22 21:00 | US Cremonese | Ternana Calcio | 3:2 |
| 8-8-22 21:15 | FC Bologna | Cosenza Calcio | 1:0 |