| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 29-7-22 18:00 | Dynamo Dresden | VfB Stuttgart | 0:1 |
| 29-7-22 18:00 | TSG Neustrelitz | Karlsruher SC | 0:8 |
| 29-7-22 18:00 | 1. FC Kaan-Marienborn | 1. FC Nürnberg | 0:2 |
| 29-7-22 20:46 | TSV 1860 München | Borussia Dortmund | 0:3 |
| 30-7-22 13:01 | Viktoria 1889 Berlin | VfL Bochum | 0:3 |
| 30-7-22 13:01 | SV Straelen | FC St. Pauli | 3:4 |
| 30-7-22 15:31 | Jahn Regensburg | 1. FC Köln | 6:5n.p. |
| 30-7-22 15:31 | FC Einheit Wernigerode | SC Paderborn 07 | 0:10 |
| 30-7-22 15:31 | VfB Lübeck | FC Hansa Rostock | 1:0 |
| 30-7-22 15:31 | SV Elversberg | Bayer 04 Leverkusen | 4:3 |
| 30-7-22 15:31 | SpVgg Bayreuth | Hamburger SV | 1:3n.v. |
| 30-7-22 15:31 | FV Illertissen | 1. FC Heidenheim 1846 | 0:2 |
| 30-7-22 18:01 | Stuttgarter Kickers | SpVgg Greuther Fürth | 2:0 |
| 30-7-22 18:01 | FC Carl Zeiss Jena | VfL Wolfsburg | 0:1 |
| 30-7-22 18:01 | Kickers Offenbach | Fortuna Düsseldorf | 1:4 |
| 31-7-22 13:01 | BSV Rehden | SV Sandhausen | 0:4 |
| 31-7-22 13:01 | Bremer SV | FC Schalke 04 | 0:5 |
| 31-7-22 15:31 | Blau-Weiß Lohne | FC Augsburg | 0:4 |
| 31-7-22 15:31 | SV Oberachern | Bor. Mönchengladbach | 1:9 |
| 31-7-22 15:31 | FV Engers 07 | Arminia Bielefeld | 1:7 |
| 31-7-22 15:31 | 1. FC Kaiserslautern | SC Freiburg | 1:2n.v. |
| 31-7-22 15:31 | TSV Schott Mainz | Hannover 96 | 0:3 |
| 31-7-22 15:31 | SV Rödinghausen | 1899 Hoffenheim | 0:2n.v. |
| 31-7-22 18:01 | Eintracht Braunschweig | Hertha BSC | 10:9n.p. |
| 31-7-22 18:01 | Erzgebirge Aue | FSV Mainz 05 | 0:3 |
| 31-7-22 18:01 | SV Waldhof Mannheim | Holstein Kiel | 5:3n.p. |
| 1-8-22 18:01 | Chemnitzer FC | 1. FC Union Berlin | 1:2n.v. |
| 1-8-22 18:01 | Energie Cottbus | Werder Bremen | 1:2 |
| 1-8-22 18:01 | FC Ingolstadt | SV Darmstadt 98 | 0:3 |
| 1-8-22 20:46 | 1. FC Magdeburg | Eintracht Frankfurt | 0:4 |
| 30-8-22 20:46 | FC Teutonia 05 Ottensen | RB Leipzig | 0:8 |
| 31-8-22 20:46 | FC Viktoria Köln | FC Bayern München | 0:5 |