| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 21-5-21 21:00 | UD Levante | FC Cadiz | 2:2 |
| 22-5-21 18:00 | Real Valladolid | Atletico Madrid | 1:2 |
| 22-5-21 18:00 | Real Madrid | FC Villarreal | 2:1 |
| 22-5-21 18:00 | SD Huesca | FC Valencia | 0:0 |
| 22-5-21 18:00 | CA Osasuna | Real Sociedad | 0:1 |
| 22-5-21 18:00 | Celta Vigo | Real Betis Sevilla | 2:3 |
| 22-5-21 18:00 | FC Elche | Athletic Bilbao | 2:0 |
| 22-5-21 18:00 | SD Eibar | FC Barcelona | 0:1 |
| 23-5-21 18:30 | FC Granada | FC Getafe | 0:0 |
| 23-5-21 21:00 | FC Sevilla | Deportivo Alaves | 1:0 |