| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 22-10-22 14:00 | Rayo Vallecano | FC Cadiz | 5:1 |
| 22-10-22 16:15 | Real Valladolid | Real Sociedad | 1:0 |
| 22-10-22 18:30 | FC Valencia | RCD Mallorca | 1:2 |
| 22-10-22 21:00 | Real Madrid | FC Sevilla | 3:1 |
| 23-10-22 14:00 | Espanyol Barcelona | FC Elche | 2:2 |
| 23-10-22 16:15 | Real Betis Sevilla | Atletico Madrid | 1:2 |
| 23-10-22 18:30 | FC Girona | CA Osasuna | 1:1 |
| 23-10-22 18:30 | FC Villarreal | UD Almeria | 2:1 |
| 23-10-22 21:00 | FC Barcelona | Athletic Bilbao | 4:0 |
| 24-10-22 21:00 | Celta Vigo | FC Getafe | 1:1 |