| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 27-5-22 21:00 | Real Sociedad B | Real Saragossa | 1:2 |
| 27-5-22 21:00 | CD Mirandes | CF Fuenlabrada | 5:1 |
| 28-5-22 18:15 | SD Amorebieta | SD Ponferradina | 1:0 |
| 28-5-22 18:15 | CD Lugo | FC Malaga | 1:0 |
| 29-5-22 20:00 | Burgos CF | FC Girona | 0:0 |
| 29-5-22 20:00 | CD Leganes | UD Almeria | 2:2 |
| 29-5-22 20:00 | Real Oviedo | UD Ibiza Eivissa | 3:2 |
| 29-5-22 20:00 | Sporting Gijon | UD Las Palmas | 0:1 |
| 29-5-22 20:00 | AD Alcorcon | SD Eibar | 1:0 |
| 29-5-22 20:00 | CD Teneriffa | FC Cartagena | 1:2 |
| 29-5-22 20:00 | Real Valladolid | SD Huesca | 3:0 |